原帖引用 · AI 翻译
Anthropic 的生物学实验室借助 Claude，在细菌及感染细菌的病毒中发现并绘制出穹窿颗粒的结构。这种中空的桶状蛋白质结构自 1986 年起就存在于人类细胞中，却一直未得到解释；此前也无人证实它存在于细菌及其病毒中。
> Claude 执行了实际的湿实验流程，而不只是阅读文献，将颗粒分离所需时间从 3 天缩短到约 90 分钟，并在 34 小时内交出了首个 3D 结构模型，而不是耗费数周。
我们在此分享生物学研究团队如何与 Claude 合作，绘制出首个来自细菌生命的穹窿颗粒 3D 结构。
穹窿颗粒是一个由来已久的谜团。它们呈桶状，是我们细胞中发现的最大的蛋白质结构之一。Leonard Rome 和 Nancy Kedersha 于 1986 年首次发现了它们，但其功能至今仍不清楚。
借助 Claude，我们获得了一些或许能让我们更接近解开这个谜团的结果。
迄今为止，人们只知道穹窿颗粒存在于动物和植物等复杂生物的细胞中。我们已经证明，来自细菌（以及感染它们的病毒）的类似蛋白质也能组装成穹窿颗粒。在这些较简单的生命形式中发现这种结构，或许能让我们更容易研究它在自身细胞中的功能。
对我们的生命科学团队而言，这个项目也展示了利用 AI 加速科学研究的潜力（及其局限性）。
在完整文章中，我们讨论了 Claude 如何大幅加快某些阶段的工作：手工确定穹窿颗粒的结构原本需要数周到数月的艰苦工作，但这次只用了几天。我们还讨论了 Claude 在过程中犯下的一些简单错误，以及我们如何与机器学习研究人员合作解决这些错误。
阅读更多：https://t.co/KowVVCSPp8
原文
We’re sharing how our biology research team worked with Claude to map the first 3D structure of a vault particle from bacterial life. Vault particles are a longstanding mystery. They are barrel-shaped objects, among the largest protein structures found in our cells. They were first discovered by Leonard Rome and Nancy Kedersha in 1986, but their function remains unknown. With Claude, we’ve found results that might bring us closer to solving that mystery. Until now, vaults were only known in the cells of complex things like animals and plants. We have shown that similar proteins from bacteria (and the viruses that infect them) can also assemble into vaults. Finding the structures in these simpler forms of life may make it easier to investigate their function in our own cells. For our life sciences team, the project was also a demonstration of the potential (and the limitations) of using AI to accelerate science. In our full piece, we discuss how Claude was able to dramatically speed up some stages—manually determining the vault particle’s structure would have taken weeks to months of painstaking work, but here it took days. We also discuss how Claude made some simple mistakes along the way, and how we collaborated with our machine learning researchers to address them. Read more: https://t.co/KowVVCSPp8